Example placental DNA methylation data

Source: R/data.r

6 DNA methylation profiles from preeclampsia and healthy control placentas. This data was downloaded from:

"Genome wide DNA methylation profiling of normal and preeclampsia placental samples. Illumina Infinium HumanMethylation450 BeadChip (450K array) was used to obtain DNA methylation profiles in placental samples. Samples included 16 samples from healthy uncomplicated pregnancies and 8 samples from pregnancies affected by preeclampsia." - from Yeung et al.

The DNA methylation data for 24 placental samples were downloaded from GSE75196. After normalizing using minfi::preprocessNoob and wateRmelon::BMIQ, the data were filtered to 6/24 samples and 10,000 random CpGs + those CpGs used in the gestational age clock and ethnicity classifier.

Reference: Yeung KR, Chiu CL, Pidsley R, Makris A et al. DNA methylation profiles in preeclampsia and healthy control placentas. Am J Physiol Heart Circ Physiol 2016 May 15;310(10):H1295-303. PMID:26968548

data(plBetas)

Format

A matrix